Discuss how tolerance may be induced to the gut microbiome, with reference to B cells and T cells

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“All disease begins in the gut”
The gut microbiome is crucial for health and homeostasis. In fact, it is so important that our
bodies revere the gut microbiome, allowing it special immune privilege.
Discuss:
a) how tolerance may be induced to the gut microbiome, with reference to B cells and T
cells
b) the role of the gut microbiome in health and disease, and how our understanding of this
might lead to therapies for immune disorders, including examples of early attempts to target the microbiome for therapy (hint: i) refer to the regulation exerted by bacterial products ii) the evidence for the influence of the gut microbiome on immune disorders, both in humans and mice).
Refer to lecture material, publications discussed during lectures, and 1-2 publications of your own finding. Include a reference list (not included in word count).
– Hippocrates.

 

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