The exploration of different cutoffs of glucocorticoid dose using metabolomics

Discuss the social, ethical, and economical impact of your product, service, or application on the organization
July 30, 2019
Blood Cells and the Hematopoietic System
July 30, 2019

-The exploration of different cutoffs of glucocorticoid dose using metabolomics
-A cut off between physiological replacement and pharmacological therapy (based on prednisolone equivalent dose)
– some researchers said that the physiological level of glucocorticoids is 2.5 mg prednisolone equivalent daily , and patients receiving glucocorticoids treatment above 5 mg prednisolone equivalent daily should start having bisphosphonate in order to avoid osteoporosis. Some side effects such as hypertension, insulin resistance etc.. might appear when a patient has > 7.5 mg prednisolone equivalent daily, other side effects such as infectious diseases due to deterioration in immune system appears when the dose exceeds 10 mg daily
– the cutoffs above were determined based on clinical and pharmacological studies, what I want to examine in this paper is The ability of metabolomics to discriminate at some but not other cutoffs

 

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